Leukotriene C4 synthase polymorphisms and responsiveness to leukotriene antagonists in asthma

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Airway responsiveness to leukotriene C4 (LTC4), leukotriene E4 (LTE4) and histamine in aspirin-sensitive asthmatic subjects.

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INTRODUCTION Leukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism of LTC4S gene and asthma, asthma phenotypes (aspirin intolerant/tolerant asthma) and different characteristics of the pat...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 2003

ISSN: 0306-5251

DOI: 10.1046/j.1365-2125.2003.01952.x